• A dearth of evidence on the treatment of TNBC in elderly women persists despite the fact that the population is becoming older.
• In this study, we did a systematic assessment of the peer-reviewed and unpublished literature to capture the treatment and breast-cancer-specific survival (BCSS) of women under the age of 70 who were diagnosed with triple negative breast cancer (TNBC).
• Five research were selected for inclusion from a total of 739 publications.

What are triple-negative breast cancers (TNBCs)?

Because triple-negative breast cancers (TNBC), which do not express the estrogen receptor (ER) or the progesterone receptor (PR), are more common in younger women, they are sometimes referred to as hormone-insensitive breast cancers (HIBC).

Should older women with triple negative cancer get chemotherapy?

• Chemotherapy is often used only in the most severe cases in older women.
• Radiation therapy appears to be underutilized in the case of elderly women as well.
• However, one research discovered that, despite the fact that they had not had adjuvant chemotherapy, older triple negative women had outcomes that were comparable to those of younger patients, of whom almost half had undergone chemotherapy.

Is TNBC caused by stress?

TNBC cells are damaged by stress hormones, which cause DNA damage.

Where does TNBC usually recur?

When recurrences of triple-negative breast cancer do occur, they often occur within the first five years of the patient’s initial diagnosis. The peak incidence occurs around three years after the initial diagnosis. Recurrences of hormone- or HER2-positive breast cancer can occur locally, regionally, or far away from the original site of the malignancy (metastatic).

Where does TNBC spread to first?

Among TNBC patients, the route of first metastasis was shown to be strongly associated with survival, with brain metastases being the poorest predictor of survival, followed by metastases to the liver, pleura, bone, and lung.

How long does it take for TNBC to metastasize?

According to studies, over 75% of recurrences occur within 3 years after diagnosis, with the majority occurring within 5 years. The findings of a 2018 Brazilian study indicated that tumours that had progressed to the lymph nodes, cancers that were in a later stage, or cancers that had both were related with increased recurrence rates in women with triple-negative breast cancer.

Is TNBC a death sentence?

TNBC is not a death sentence, as many people believe! Patients should be informed that there are effective therapies for this condition and that they have a chance of surviving. Make a point of mentioning that TNBC is highly responsive to chemotherapy and that a large number of clinical trials are available if normal treatment becomes unsuccessful.

What causes triple negative?

A BRCA1 gene mutation is thought to make the body’s cells more vulnerable to subsequent genetic modifications, which can result in specific types of cancer, including various forms of breast and ovarian cancer, according to research. BRCA1 gene damage is the leading cause of triple-negative breast cancer in the United States.

How long can you live with triple negative?

Survival rates for triple-negative breast cancer at five years are as follows:

Does TNBC always come back?

Recurrence. Although triple-negative breast cancer is more likely than other kinds of breast cancer to spread to other parts of the body, the likelihood of this occurring decreases with time. The risk reaches its maximum approximately three years after starting therapy and then rapidly declines after that.

Can TNBC be cured?

It may be cured in some cases, but it is not always the case. TNBC has a high recurrence rate, which is highest in the first three years after diagnosis. After 5 years, however, there is a significant decrease in the number of recurrences. As a result, there are no extensive post-treatment routines.

What are the stages of TNBC?

• Stage 1 malignancies are small, localized tumors that have not progressed beyond a single lymph node in the vicinity.
• Regional malignancies in the underarm area that are moderate in severity and have not migrated beyond the lymph nodes are classified as stage 2.
• The third stage of breast cancer is marked by the presence of cancer that has progressed beyond the breast but has not gone to other organs.

What does TNBC feed on?

There is currently no optimal diet for persons who have TNBC, according to research. A whole-foods diet rich in fruits and vegetables, whole grains, and legumes appears to be advantageous in both preventing cancer and maintaining health throughout cancer treatment, according to the data.

Why is the liver a common site for metastasis?

Because of its abundant and dual blood supply, the liver is a popular location for metastatic illness (the liver receives blood via the hepatic artery and portal vein). Hepatocellular carcinoma (HCC) is 20 times more prevalent in metastatic patients than initial tumors.

What is early stage TNBC?

Abstract. Known as triple negative breast cancer, this aggressive form of breast cancer is associated with an increased risk of recurrences and poor outcomes. Systemic chemotherapy has been shown to dramatically improve long-term outcomes in individuals with early-stage cancer; nonetheless, metastatic recurrences continue to occur in a considerable proportion of patients after treatment.

What Is a Stage 2 tumor?

Stage 2 cancer refers to tumors or malignancies that are greater in size and have penetrated further into adjacent tissue. At this stage, the cancer may have gone to the lymph nodes, but it has not migrated to other regions of the body at this point. Stage 2 cancers are more advanced than stage 1 cancers, despite the fact that they are not called advanced malignancies.

What is triple negative?

Specifically, triple-negative breast cancer is a kind of breast cancer that lacks any of the receptors that are usually seen in breast cancer. Consider cancer cells to be like a home. The front door may contain three types of locks, referred to as receptors: one for the female hormone estrogen; two for the male hormone testosterone; and three for the male hormone testosterone.

Are older women more likely to get breast cancer?

The number of older women diagnosed with breast cancer will rise by an absolute factor of 80 percent as a result of this increase.